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KMID : 1098420090170040257
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Korean Journal of Medicinal Crop Science
2009 Volume.17 No. 4 p.257 ~ p.265
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Enhancement of Immuno-modulatory of Centella asiatica L. Urban with Edible Polymer through Nano-encapsulation Process
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Ha Ji-Hye
Kwon Min-Cheol
Hwang Baik
Jeong Myeong-Hoon
Lee Hyeon-Yong
Kim Seung-Seop
Kim Young
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Abstract
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Phosphatidylcholine was used to encapsulate aqueous extracts of Centella asiatica, and its biological activity was compared with another aqueous extracts. Nanoparticle of C. asiatica was made by encapsulation to w/o type spherical liposome which of aqueous extracts seized with oil phase as 78.2 nm average diameter. Cytotoxicity of the nanoparticle was measured on human skin fibroblast cells, CCD-986sk, and showed lower cytotoxicity on 1.0 mg/ of highest concentration as 28% than that of another extracts. The nanoparticle showed the highest promotion of human B and T cell growth up to 138% and 135%, respectively, compared to the control. and the NK cell growth was promoted up to 8% higher than the control in proportion to secretion of IL-6 and TNF- from immune cell growth. Also nanoparticle showed highest inhibition activity of hyaluronidase on 1.0 mg/ of highest concentration as 60.5%. It seems that because of enhanced biological application of aqueous extracts on cell through nano-encapsulation process.
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KEYWORD
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Centella asiatica L. Urban, Nanoparticle, Immune Activity
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